40th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC’18), July 17 – 21, Honolulu, HI

Invited Session (Thursday, July 19, 2018, 10:00-11:30): Sensors and actuators for 3D constructs of living cells 

Schulze, Frank: A Microfluidic Bioreactor for a Physiologic Bone-On-A-Chip System

Organ-on-a-chip technology has a high potential to create the physiologic environment that can be found in the tissue of interest in vivo. In this project, a bone-on-a-chip system is developed that allows for the application and quantification of mechanical load and the regulation of oxygen levels.

Koch, Martin, Wiest, Joachim: Magnetic versus Electromagnetic-Fields and the Specific Low Frequent Application in Biophysics

The two terms magnetic and electromagnetic had been defined by J.C. Maxwell in 1855. The first is a DC or low frequent-the second a high frequent field application. In the high frequent application, material constants cannot be neglected and herewith a certain heat generation, which is intended in biomed applications, e.g. Hyperthermia. Here however we avoid to heat up the treated cells and work magnetically (low frequently) with tagged magnetic particles like SPIONs.

Koch, Martin, Wiest, Joachim: From Operating Heavy Duty Electric Machines to Application of Magnetic Particles Inside Living Cells/Cell-Spheres

Heavy Duty industrial machines are operated with large electric fields safely controlled by a suitable insulation, e.g. a long bushing. Living cells are efficient organic heavy duty systems with a membrane capable to insulate gigantic electric fields higher as such devices, mentioned above. That brought up the idea to apply dynamic (superposed, locally displaced) heavy duty field techniques into the environment of living cells. In one case we move magnetic particles individually (each one of the bulk separately field powered) above the surface of the cell membrane, in order to insert them endocytotically. This application is cold meaning negligible, nearly non-detectible, heat is produced inside the particles.

Wiest, Joachim: Systems Engineering for Microphysiometry

In the presented work a system for monitoring of living cells is described. Its different modules for cell culture, sensor readout and data processing are presented and examples for applications in toxicology and environmental monitoring are enlighten.